A Facile Synthesis and Characterization of Biologically Active Halogen Substituted 1-Acetyl 3, 5-Diphenylpyrazole Derivatives

Flavonoids comprise a large family of plant derived polyphenolic compounds classified as flavonols, chalcones, aurones, flavanones, isoflavones, flavans, flavanonols, flavanols, and flavones differencing from each other in their structural group arrangements [1]. α,β-Unsaturated ketones display a wide range of pharmacological properties, including cytotoxicity towards different cancer cell lines [2,3], antibiotic [4], antibacterial [5], antiviral [6], anti-inflammatory [7] and hepatoprotective activities [8]. They are well known intermediates for synthesizing various heterocyclic compounds like pyrazoline and pyrimidine derivatives. A survey of literature in the recent past reveals that some pyrazole derivatives possess antibacterial [9], antiinflammatory [10] and antifungal effects [11]. In the view of the above mentioned facts and our continued interest in the synthesis of heterocyclic compounds derived from chalcone precursors [12,13], it was thought of interest to synthesize some new heterocyclic compounds containing pyrazole rings [14,15] and examine their antimicrobial properties.